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Cough syrup also known as lean is an illicit substance made with codeine cough syrup, soda, and hard candy. Codeine is derived from the opium poppy plant (similar to morphine).Promethazine/codeine is an expensive drug used as a cough suppressant, a decongestant, and an antihistamine. It helps to stop or reduce coughing and congestion. It is more popular than comparable drugs. Promethazine/codeine is only available as a generic drug. Generic promethazine/codeine is covered by most Medicare and insurance plans, but some pharmacy coupons.Cough syrup also known as lean contain Promethazine which is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. It can sometimes close up the bronchial tubes (air passages of the lungs) and make breathing difficult. Codeine belongs to the group of medicine called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.